1H-Pyrazolo[4,3-g]benzothiazol-7-amine
نویسندگان
چکیده
The mol-ecule of the title compound, C(8)H(6)N(4)S, is almost planar [maximum deviation from the mean plane = 0.020 (1) Å for the S atom]. In the crystal, a supra-molecular three-dimensional arrangement arises from N-H⋯N hydrogen bonds and weak aromatic stacking interactions along the a axis [centroid-centroid separation = 3.582 (2) Å].
منابع مشابه
Synthesis and isomerization of some novel pyrazolopyrimidine and pyrazolotriazolopyrimidine derivatives.
4-Imino-1-p-tolyl-1,4-dihydropyrazolo[3,4-d]pyrimidin-5-ylamine (2) and (1-p-tolyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-hydrazine (3) were prepared starting from ethyl 4-cyano-1-p-tolyl-1H-pyrazol-5-ylimidoformate (1). The structure of compound 3 was confirmed through preparation of the pyrazole derivatives 4 and 5. Also, the synthesis and structural characterization of pyrazolo[4,3-e][1,2,4]triaz...
متن کاملInteraction of Bioactive Pyrazolo[4,3-a]acridines with Human Serum Albumin
Several heterocyclic bioactive fluorescent 3-alkyl-3H-pyrazolo[4,3-a]acridin-11-carbonitriles were conveniently synthesized from the reaction of 1-alkyl-1H-indazoles with different aryl acetonitrile in basic methanol solution in good yields. The interactions of 3H-pyrazolo[4,...
متن کاملTautomerism and pKa behaviour of 1-hydroxypyrazoloquinolines and pyrazoloisoquinolines
The recently-synthesised novel heterocyclic isomers 3-hydroxy-3H -pyrazolo[3,4-c ]isoquinoline (1), 3-hydroxy-3H -pyrazolo[3,4-c ]quinoline (2), 1-hydroxy-1H -pyrazolo[4,3-c ]isoquinoline (3) and 1-hydroxy-1H -pyrazolo[4,3-c ]quinoline (4) show remarkable differences in properties and reactivity, both between each other and compared with the simpler parent compound 1-hydroxypyrazole (0), despit...
متن کاملSynthesis and antimicrobial activity of some new pyrazole, fused pyrazolo[3,4-d]-pyrimidine and pyrazolo[4,3-e][1,2,4]-triazolo[1,5-c]pyrimidine derivatives.
Hydrazonyl bromides 2a,b reacted with active methylene compounds (dibenzoylmethane, acetylacetone, ethyl acetoacetate, phenacyl cyanide, acetoacetanilide, ethyl cyanoacetate, cyanoacetamide and malononitrile) to afford the corresponding 1,3,4,5- tetrasubstituted pyrazole derivatives 5-12a,b. Reaction of 12a,b with formamide, formic acid and triethyl orthoformate give the pyrazolo[3,4-d]pyrimidi...
متن کاملSynthesis of trifluoromethyl-substituted pyrazolo[4,3-c]pyridines – sequential versus multicomponent reaction approach
A straightforward synthesis of 6-substituted 1-phenyl-3-trifluoromethyl-1H-pyrazolo[4,3-c]pyridines and the corresponding 5-oxides is presented. Hence, microwave-assisted treatment of 5-chloro-1-phenyl-3-trifluoromethylpyrazole-4-carbaldehyde with various terminal alkynes in the presence of tert-butylamine under Sonogashira-type cross-coupling conditions affords the former title compounds in a ...
متن کامل